DNA methylation subtype and H3K27Me3 status of a case of clear‐cell meningioma of the lateral sphenoid wing

Authors

  • Aaron Song Chuan Foo Department of Surgery, Division of Neurosurgery, National University Hospital, Singapore
  • Bingcheng Wu Department of Pathology, National University Hospital, Singapore
  • Felix Sahm Department of Neuropathology, Institute of Pathology, University Heidelberg, Heidelberg, Germany
  • Shilin Wang Department of Surgery, Division of Neurosurgery, National University Hospital, Singapore
  • Lwin Sein Department of Surgery, Division of Neurosurgery, National University Hospital, Singapore

Keywords:

Clear-cell meningioma, DNA methylation, H3K27me3

Abstract


We report a case of lateral sphenoid wing clear-cell meningioma in a 68-year-old male. Clear-cell meningiomas account for 0.2%–0.8% of meningiomas and are notorious for their aggressive clinical behavior. To our surprise, DNA methylation profiling and H3K27Me3 testing suggested an indolent meningioma subtype in our patient’s case. This case illustrates discrepancies between histopathological and molecular-based classification systems and highlights the importance of considering the molecular profile of tumors during prognostication.

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Published

2022-08-17

How to Cite

Aaron Song Chuan Foo, Bingcheng Wu, Felix Sahm, Shilin Wang, & Lwin Sein. (2022). DNA methylation subtype and H3K27Me3 status of a case of clear‐cell meningioma of the lateral sphenoid wing. International Journal of Clinicopathological Correlation, 3(2), 67–69. Retrieved from https://www.editorialmanager.in/index.php/ijcpc/article/view/393

Issue

Vol. 3 No. 2 (2019): Jul-Dec

Section

Case Report

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.